Central Angiotensin II ‐ induced hypertension downregulates AT2R and the mir‐29 family in rats
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چکیده
منابع مشابه
Crocin prevents acute angiotensin II-induced hypertension in anesthetized rats
Objective: Angiotensin II (Ang II), the main product of renin-angiotensin system (RAS) has a well-known role in cardiovascular regulation. Over-production of Ang II is one of the important underlying mechanisms of hypertension. In this study, the effect of crocin on cardiovascular responses in rats with acute hypertension induced by Ang II was evaluated. Materials and methods: Rats were divided...
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Many studies have implicated both angiotensin II (ANG II) and aldosterone (Aldo) in the pathogenesis of hypertension, the progression of renal injury, and cardiac remodeling after myocardial infarction. In several cases, ANG II and Aldo have been shown to have synergistic interactions in the periphery. In the present studies, we tested the hypothesis that ANG II and Aldo interact centrally in A...
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Acute subcutaneous administration of angiotensin-II (Ang II-150μg/kg) causes a rise in blood pressure in normal Wistar rats. Administration of Punica granatum juice extract (PJ100 mg/kg and 300 mg/kg; p.o.) for 4 weeks in angiotensin-II treated rats significantly (P<0.05) reduced the mean arterial blood pressure and vascular reactivity changes to various catecholamines. PJ treatment significant...
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Losartan, an AT1 angiotensin II (ANG II) receptor non-peptide antagonist, induces an increase in mean arterial pressure (MAP) when injected intracerebroventricularly (icv) into rats. The present study investigated possible effector mechanisms of the increase in MAP induced by icv losartan in unanesthetized rats. Male Holtzman rats (280-300 g, N = 6/group) with a cannula implanted into the anter...
متن کاملCrocin prevents acute angiotensin II-induced hypertension in anesthetized rats
OBJECTIVE Angiotensin II (Ang II), the main product of renin-angiotensin system (RAS) has a well-known role in cardiovascular regulation. Over-production of Ang II is one of the important underlying mechanisms of hypertension. In this study, the effect of crocin on cardiovascular responses in rats with acute hypertension induced by Ang II was evaluated. MATERIALS AND METHODS Rats were divided...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.697.25